Cytotoxic T lymphocytes form an antigen-independent ring junction
نویسندگان
چکیده
منابع مشابه
Cytotoxic T lymphocytes form an antigen-independent ring junction.
Immunological synapses are organized cell-cell junctions between T lymphocytes and APCs composed of an adhesion ring, the peripheral supramolecular activation cluster (pSMAC), and a central T cell receptor cluster, the central supramolecular activation cluster (cSMAC). In CD8(+) cytotoxic T lymphocytes, the immunological synapse is thought to facilitate specific killing by confining cytotoxic a...
متن کاملAntigen Recognition by Cloned Cytotoxic T Lymphocytes
Antigen recognition by cytotoxic lymphocytes (CTL) 1 and by helper T cells is restricted by gene products of the major histocompatibility complex (MHC), called H-2 in the mouse (1). CTL recognize antigens in the context of Kand D-regionencoded structures, whereas helper T cells recognize antigen in the context of I-regionencoded structures. This H-2 restriction appears to be very tight: C T L s...
متن کاملThe role of antigen-independent persistence of memory cytotoxic T lymphocytes.
We use mathematical models to analyze the role of a memory cytotoxic T lymphocyte (CTL) response in viral infections. The model predicts that antigen-independent persistence of an elevated number of precursor CTL (CTLp) does not protect the host from clinical symptoms upon re-infection. Instead, we find that antigen-independent long-term persistence of CTLp is required to clear virus infections...
متن کاملAntigen receptor-regulated exocytosis in cytotoxic T lymphocytes
We demonstrate here that T cell receptor for antigen (TCR)-triggered exocytosis in cytotoxic T lymphocytes (CTL) is not constitutive and is regulated through crosslinking of the TCR by antigen or monoclonal anti-TCR antibodies. Morphological and biochemical data using three different biochemical markers of granules and Percoll gradient fractionation analysis are presented, suggesting that TCR-t...
متن کاملAntigen presentation to cytotoxic T lymphocytes in vivo
T he elucidation of the separate pathways of antigen presentation by MHC class II molecules to CD4 + T cells and by MHC class I molecules to CD8 + T cells has provided an understanding of how CD4 + helper responses can be directed at extracellular antigens while CD8 + cytotoxic responses can be directed against intracellular antigens. Both dass I and class II molecules are made in the endoplasm...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2004
ISSN: 0021-9738
DOI: 10.1172/jci200419337